Everyday scientists and medical doctors work together to discover possible treatments, more likely a better one, for various medical diseases. Up until now, several medical conditions remain incurable such as AIDS and Cancer. But with continuous medical study and experimentation, some experiments have shown promising results, for an instance in autoimmune diseases such as that with liposomal clodronate.
True enough, the results on the several studies for such therapy were very promising, offering a new hope for patient suffering from immune system abnormalities. Liposome clodronate differs from any kind of therapy as it is delivered intracellularly. With the use of several advancements in medical therapy, treatment of medical diseases have become quite sophisticated indeed.
There are countless of cells that make up the immune system, macrophages however is said be the core of it. Its primary function is to activate natural immunity and regulate non-phagocytic cells. Macrophages play an important role in natural immune response and immunity, and are responsible in maintaining homeostasis by ingesting and digesting microorganism.
In other words, under normal circumstances the immune system is helpful. However, for some reason the immune system may not be functioning how it's supposed to be. In fact, it may cause diseases in the body thus the term, autoimmune disease meaning, "self'' made disease. Your own immune system is fighting with your own healthy cells and without medical intervention disease will progress rather quickly.
Macrophages can be a good thing or bad thing. For an instance, in simple virus infection the macrophages will be the one to fight with the virus thus preventing further infection. But in certain autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and so on, macrophages are fighting against your healthy cells which caused such diseases.
Clodronic acid is administered through the trachea, directly into the lungs and absorbed by the blood stream. Using liposomes as vehicle, the liposome will be ingested by the macrophages through endocytosis. Certain chemicals inside the cells will disrupt the layer of the liposome releasing the clodronate. There will be an accumulation of clodronic acid inside the macrophage and after exceeding threshold, will cause the macrophage to die through apoptosis.
The mechanism of action on such therapy by far remains to be the most promising form treatment. Immune system suppression is not a new patient management or treatment for certain medical diseases, there have been several oral, parenteral or intravenous drugs were already made to achieve similar results. But some patients remain unresponsive.
With the discovery of clodronic acid therapy, these possibilities may be the least of your concerns. Through the use of liposomes as the drug vehicle the main drug, clodronic acid will be delivered inside the macrophages and after exceeding its threshold, dies by apoptosis. Liposomes are easily engulfed by macrophages which makes it a great choice as a drug vehicle. As the drug is delivered directly into the phagocytic cells, there's a greater chance of suppressing the immune system.
The liposomal clodronate is no doubt a wonder drug as far as autoimmune diseases and transplantation is concerned. Medical studies and experiments are still going on for the therapeutic effect of such therapy in anti neoplastic drugs or Cancer in particular.
True enough, the results on the several studies for such therapy were very promising, offering a new hope for patient suffering from immune system abnormalities. Liposome clodronate differs from any kind of therapy as it is delivered intracellularly. With the use of several advancements in medical therapy, treatment of medical diseases have become quite sophisticated indeed.
There are countless of cells that make up the immune system, macrophages however is said be the core of it. Its primary function is to activate natural immunity and regulate non-phagocytic cells. Macrophages play an important role in natural immune response and immunity, and are responsible in maintaining homeostasis by ingesting and digesting microorganism.
In other words, under normal circumstances the immune system is helpful. However, for some reason the immune system may not be functioning how it's supposed to be. In fact, it may cause diseases in the body thus the term, autoimmune disease meaning, "self'' made disease. Your own immune system is fighting with your own healthy cells and without medical intervention disease will progress rather quickly.
Macrophages can be a good thing or bad thing. For an instance, in simple virus infection the macrophages will be the one to fight with the virus thus preventing further infection. But in certain autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and so on, macrophages are fighting against your healthy cells which caused such diseases.
Clodronic acid is administered through the trachea, directly into the lungs and absorbed by the blood stream. Using liposomes as vehicle, the liposome will be ingested by the macrophages through endocytosis. Certain chemicals inside the cells will disrupt the layer of the liposome releasing the clodronate. There will be an accumulation of clodronic acid inside the macrophage and after exceeding threshold, will cause the macrophage to die through apoptosis.
The mechanism of action on such therapy by far remains to be the most promising form treatment. Immune system suppression is not a new patient management or treatment for certain medical diseases, there have been several oral, parenteral or intravenous drugs were already made to achieve similar results. But some patients remain unresponsive.
With the discovery of clodronic acid therapy, these possibilities may be the least of your concerns. Through the use of liposomes as the drug vehicle the main drug, clodronic acid will be delivered inside the macrophages and after exceeding its threshold, dies by apoptosis. Liposomes are easily engulfed by macrophages which makes it a great choice as a drug vehicle. As the drug is delivered directly into the phagocytic cells, there's a greater chance of suppressing the immune system.
The liposomal clodronate is no doubt a wonder drug as far as autoimmune diseases and transplantation is concerned. Medical studies and experiments are still going on for the therapeutic effect of such therapy in anti neoplastic drugs or Cancer in particular.
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When you need the best source for high quality liposomal clodronate, click the link to www.clodrosome.com. For more details on Encapsula NanoSciences. Visit us at http://www.clodrosome.com today.
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